Testosterone replacement helps

A recent paper in the International Journal of Endocrinology And Metabolism (1) dealt with hormone replacement therapy carried out in hypogonadotropic hypogonadal (HH) men. The authors described a successful procedure involving the use of gonadotropin-like substances and testosterone (T) to fight infertility in HH men. The findings of the study suggested that the procedure could lead to successful sexual relationships and conception. Despite the important role played by these hormones, the design of experiments aimed at better defining guidelines for T use in various pathological conditions, other than those related to reproductive functions, is still rare. In the present letter, I wish to underline some aspects of this attitude.