13C and 1H NMR parameters were measured for isoproterenol in solution. Spin-lattice relaxation rates were considered and C-H and H-H J couplings were determined. The t rotamer was shown to occur in a much greater abundance than the two g rotamers. Dynamics in solution were interpreted in terms of a nearly isotropic motion of the α-hydroxyphenethyl moiety and of a high degree of flexibility of the isopropyl moiety, Relevant distances and dipolar connectivities were measured and used to build up a Dreiding model of the most probable conformation.

Gaggelli, E., Marchettini, N., Valensin, G. (1987). 1H and 13C NMR conformational analysis in solution of isoproterenol a pure β-agonist drug. MAGNETIC RESONANCE IN CHEMISTRY, 25(11), 970-974 [10.1002/mrc.1260251109].

1H and 13C NMR conformational analysis in solution of isoproterenol a pure β-agonist drug

Gaggelli, E.;Marchettini, N.;Valensin, G.
1987-01-01

Abstract

13C and 1H NMR parameters were measured for isoproterenol in solution. Spin-lattice relaxation rates were considered and C-H and H-H J couplings were determined. The t rotamer was shown to occur in a much greater abundance than the two g rotamers. Dynamics in solution were interpreted in terms of a nearly isotropic motion of the α-hydroxyphenethyl moiety and of a high degree of flexibility of the isopropyl moiety, Relevant distances and dipolar connectivities were measured and used to build up a Dreiding model of the most probable conformation.
Gaggelli, E., Marchettini, N., Valensin, G. (1987). 1H and 13C NMR conformational analysis in solution of isoproterenol a pure β-agonist drug. MAGNETIC RESONANCE IN CHEMISTRY, 25(11), 970-974 [10.1002/mrc.1260251109].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11365/33026
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