We have utilized a polymerase chain reaction (PCR) strategy to identify a novel subunit, gamma 3, of the GABAA receptor. The gamma 3 cDNA encodes a mature protein of 450 amino acids that contains structural features typically conserved among subunits of the GABAA receptor family. The gamma 3 subunit shares approximately 66% sequence identity with the gamma 2 subunit but only 38% and 29% with alpha 1 and beta 1 subunits, respectively. Localization of the gamma 3 mRNA indicates that it is widely distributed throughout the mouse brain in a pattern similar to that observed for mRNAs encoding the gamma 2 subunits.
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|Titolo:||A novel gamma subunit of the GABAA receptor identified using the polymerase chain reaction.|
|Citazione:||Wilson Shaw D, 4.5., Robinson, M., Gambarana, C., Siegel, R.e., & Sikela, J.m. (1991). A novel gamma subunit of the GABAA receptor identified using the polymerase chain reaction. FEBS LETTERS, 284(2), 211-215.|
|Appare nelle tipologie:||1.1 Articolo in rivista|