Plasma levels of soluble Fas (sFas) are elevated in human immunodeficiency virus type 1 (HIV-1) infection, indicating dysregulation of the Fas apoptosis pathway and chronic immune activation. We performed a retrospective study to investigate the effects of HAART on plasma levels of sFas. A cross-sectional study of 27 drug-naive infected subjects and 49 patients under antiretroviral treatment showed that plasma levels of sFas were higher in HIV-1-infected subjects than in 52 HIV-1-negative controls, independently of the treatment status. In a longitudinal study of 69 patients undergoing HAART, we observed a minimal, but significant decrease in sFas plasma levels after 1 year of therapy. Levels of sFas, however, remained still higher than physiologic values. Patients undergoing HAART were further classified as nonresponders or responders on the basis of viremia suppression; no significant changes in plasma levels of sFas were observed between the two groups. These findings show that 1 year of HAART has a minor effect on the sFas levels in plasma. Long-term HAART may be required to normalize the dysregulation of the Fas apoptotic pathway and the persistent immune activation initiated by HIV-1.

DE MILITO, A., Hejdeman, B., Albert, J., Aleman, S., Sonnerborg, A., Zazzi, M., et al. (2000). High plasma levels of soluble Fas in HIV type 1-infected subjects are not normalized during highly active antiretroviral therapy. AIDS RESEARCH AND HUMAN RETROVIRUSES, 16, 1379-1384.

High plasma levels of soluble Fas in HIV type 1-infected subjects are not normalized during highly active antiretroviral therapy

ZAZZI, MAURIZIO;
2000

Abstract

Plasma levels of soluble Fas (sFas) are elevated in human immunodeficiency virus type 1 (HIV-1) infection, indicating dysregulation of the Fas apoptosis pathway and chronic immune activation. We performed a retrospective study to investigate the effects of HAART on plasma levels of sFas. A cross-sectional study of 27 drug-naive infected subjects and 49 patients under antiretroviral treatment showed that plasma levels of sFas were higher in HIV-1-infected subjects than in 52 HIV-1-negative controls, independently of the treatment status. In a longitudinal study of 69 patients undergoing HAART, we observed a minimal, but significant decrease in sFas plasma levels after 1 year of therapy. Levels of sFas, however, remained still higher than physiologic values. Patients undergoing HAART were further classified as nonresponders or responders on the basis of viremia suppression; no significant changes in plasma levels of sFas were observed between the two groups. These findings show that 1 year of HAART has a minor effect on the sFas levels in plasma. Long-term HAART may be required to normalize the dysregulation of the Fas apoptotic pathway and the persistent immune activation initiated by HIV-1.
DE MILITO, A., Hejdeman, B., Albert, J., Aleman, S., Sonnerborg, A., Zazzi, M., et al. (2000). High plasma levels of soluble Fas in HIV type 1-infected subjects are not normalized during highly active antiretroviral therapy. AIDS RESEARCH AND HUMAN RETROVIRUSES, 16, 1379-1384.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11365/32070
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