The physico-chemical properties of β-lactosyl-closo-orthocarborane in water solution were investigated by multinuclear NMR,13C NMR relaxation, and ab-initio calculations. This molecule represents a potentially selective boron carrier in Boron Neutron Cancer Therapy (BNCT) and exhibits amphiphilic characteristics. Its structural and dynamic features were studied comparing NMR data acquired in both aggregating and non-aggregating conditions. Aggregates are characterized by rapid exchange with the bulk and by high sensitivity to temperature conditions. An unusually stable intra-molecular CH....O hydrogen bond was found to persist in water solution both for the free molecules and after aggregate formation. At the same time, inter-molecular specific CH ...O interactions do not seem effective in the aggregate formation process, which appears to take place only on non-specific hydrophobic basis.
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|Titolo:||Solution Behavior of a Sugar-based Carborane for Boron Neutron Capture Therapy: a Nuclear Magnetic Resonance Investigation|
|Citazione:||Bonechi, C., Ristori, S., Martini, S., Panza, L., Martini, G., Rossi, C., et al. (2007). Solution Behavior of a Sugar-based Carborane for Boron Neutron Capture Therapy: a Nuclear Magnetic Resonance Investigation. BIOPHYSICAL CHEMISTRY, 125(2-3), 320-327.|
|Appare nelle tipologie:||1.1 Articolo in rivista|