The synthesis of a series of novel amino acids and peptides containing an aziridine ring is described. Their preparation is based on the Gabriel-Cromwell reaction of amino acids or peptides with different 2-bromo acrylates and acrylamides. These products are constituted by a turned scaffold (the aziridine) where two parallel peptidic strands can be grown to produce a beta-sheet mimetic. (C) 1998 Elsevier Science Ltd. All rights reserved.
Filigheddu, S.N., Taddei, M. (1998). Small ring constrained peptidomimetics. Synthesis of aziridine parallel beta-sheet mimetics. TETRAHEDRON LETTERS, 39(22), 3857-3860 [10.1016/S0040-4039(98)00632-7].
Small ring constrained peptidomimetics. Synthesis of aziridine parallel beta-sheet mimetics
Taddei, Maurizio
1998-01-01
Abstract
The synthesis of a series of novel amino acids and peptides containing an aziridine ring is described. Their preparation is based on the Gabriel-Cromwell reaction of amino acids or peptides with different 2-bromo acrylates and acrylamides. These products are constituted by a turned scaffold (the aziridine) where two parallel peptidic strands can be grown to produce a beta-sheet mimetic. (C) 1998 Elsevier Science Ltd. All rights reserved.
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
https://hdl.handle.net/11365/31542
Attenzione
Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo