New toluidine derivatives are described. Some of them showed interesting activity against Mycobacteria. They led to an optimization of the pharmacophore model previously described by us. The best-fitted conformer of one of the most active compounds (6a) shows all the chemical groups matched to the chemical features of the model.
Biava, M., Fioravanti, R., Porretta, G.C., Deidda, D., Lampis, G., Pompei, R., et al. (2002). New derivatives of toluidine: synthesis, antitubercular activity and pharmacophore hypothesis. MEDICINAL CHEMISTRY RESEARCH, 11(1), 50-66.
New derivatives of toluidine: synthesis, antitubercular activity and pharmacophore hypothesis
A. TAFI;F. MANETTI
2002-01-01
Abstract
New toluidine derivatives are described. Some of them showed interesting activity against Mycobacteria. They led to an optimization of the pharmacophore model previously described by us. The best-fitted conformer of one of the most active compounds (6a) shows all the chemical groups matched to the chemical features of the model.
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https://hdl.handle.net/11365/3147
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