The addition of gamma-monosubstituted allylchromium(lll) reagents to N-protected alpha-amino aldehydes proceeds in a stereoconvergent manner in contrast with the case of the unsubstituted reagents, where the stereoselectivity depends on the nature of the group bonded to the nitrogen. The chromium(III) reagent derived from 3-chloromethyl-2-trimethylsilyl-1-propene was used to prepare a C-2 symmetric HIV-protease inhibitor. Copyright (C) 1996 Elsevier Science Ltd
Ciapetti, P., Falorni, M., Taddei, M. (1996). CrCl2 mediated addition of allylic halides or phosphates to N-protected alpha-amino aldehydes. Stereocontrolled synthesis of a new core for C-2 symmetric HIV-protease inhibitors. TETRAHEDRON, 52(21), 7379-7390 [10.1016/0040-4020(96)00258-X].
CrCl2 mediated addition of allylic halides or phosphates to N-protected alpha-amino aldehydes. Stereocontrolled synthesis of a new core for C-2 symmetric HIV-protease inhibitors
Taddei, Maurizio
1996-01-01
Abstract
The addition of gamma-monosubstituted allylchromium(lll) reagents to N-protected alpha-amino aldehydes proceeds in a stereoconvergent manner in contrast with the case of the unsubstituted reagents, where the stereoselectivity depends on the nature of the group bonded to the nitrogen. The chromium(III) reagent derived from 3-chloromethyl-2-trimethylsilyl-1-propene was used to prepare a C-2 symmetric HIV-protease inhibitor. Copyright (C) 1996 Elsevier Science Ltd
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https://hdl.handle.net/11365/31388
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