Bromoallenes 3a and 3b derived from (D)-Serine undergo S(N)2' alkylation with organo copper reagents to give alkynyl amino alcohol derivatives. These compounds can be further transformed into blanched enantiomerically enriched alpha-amino acids as, for example (L)-Isolcucine and (L)-Alloisoleucine.
Daniello, F., Mann, A., Taddei, M., Wermuth, C.G. (1994). 1,3-diastereocontrol With Bromoallenes - Synthesis of Enantiomerically Pure Beta-branched Alpha-amino-acids. TETRAHEDRON LETTERS, 35(42), 7775-7778 [10.1016/S0040-4039(00)77369-2].
1,3-diastereocontrol With Bromoallenes - Synthesis of Enantiomerically Pure Beta-branched Alpha-amino-acids
Taddei, Maurizio;
1994-01-01
Abstract
Bromoallenes 3a and 3b derived from (D)-Serine undergo S(N)2' alkylation with organo copper reagents to give alkynyl amino alcohol derivatives. These compounds can be further transformed into blanched enantiomerically enriched alpha-amino acids as, for example (L)-Isolcucine and (L)-Alloisoleucine.
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https://hdl.handle.net/11365/31204
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