The complexes formed by kanamycin A at three different pH values (5.5, 7.4 and 12.0) were investigated by NMR and EPR spectroscopy. The interaction of the Cu(II) ion with the nitrogen of the C ring is apparent at all pH values. At higher pH also the amino group of ring A starts to be involved in the metal coordination sphere. This is accompanied by a switch in conformation of ring C. Structures are consistent with the involvement in the coordination sphere either of the 2 or 4 hydroxyl oxygens at pH 5.5 and the 5 and the 6 hydroxyl oxygens (or the ring oxygen) at pH 12.0.

D'Amelio, N., Gaggelli, E., Gaggelli, N., Molteni, E., Baratto, M.C., Valensin, G., et al. (2004). NMR and EPR Structural Delineation of Copper(II) Complexes Formed by Kanamycin A in Water. DALTON TRANSACTIONS, 4(3), 363-368 [10.1039/b313060f].

NMR and EPR Structural Delineation of Copper(II) Complexes Formed by Kanamycin A in Water

Gaggelli, Elena;Gaggelli, N.;Baratto, Maria Camilla;Valensin, Gianni;
2004-01-01

Abstract

The complexes formed by kanamycin A at three different pH values (5.5, 7.4 and 12.0) were investigated by NMR and EPR spectroscopy. The interaction of the Cu(II) ion with the nitrogen of the C ring is apparent at all pH values. At higher pH also the amino group of ring A starts to be involved in the metal coordination sphere. This is accompanied by a switch in conformation of ring C. Structures are consistent with the involvement in the coordination sphere either of the 2 or 4 hydroxyl oxygens at pH 5.5 and the 5 and the 6 hydroxyl oxygens (or the ring oxygen) at pH 12.0.
2004
D'Amelio, N., Gaggelli, E., Gaggelli, N., Molteni, E., Baratto, M.C., Valensin, G., et al. (2004). NMR and EPR Structural Delineation of Copper(II) Complexes Formed by Kanamycin A in Water. DALTON TRANSACTIONS, 4(3), 363-368 [10.1039/b313060f].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11365/3089
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