Catalytic-transfer hydrogenation in ifo-propanol under microwave irradiation has been performed to rapidly deprotect N-Cbz and N-Bn derivatives. The method is particularly suitable for the synthesis of short peptides and can also be carried out on supported molecules. The rapid cleavage of chiral molecules derived from (S)-1-phenylethylamine can be very useful for asymmetric synthesis of nitrogen containing compounds. (C) 2001 Elsevier Science Ltd. All rights reserved.
Daga, M.C., Taddei, M., Varchi, G. (2001). Rapid microwave-assisted deprotection of N-Cbz and N-Bn derivatives. TETRAHEDRON LETTERS, 42(31), 5191-5194 [10.1016/S0040-4039(01)00969-8].
Rapid microwave-assisted deprotection of N-Cbz and N-Bn derivatives
Taddei, Maurizio;
2001-01-01
Abstract
Catalytic-transfer hydrogenation in ifo-propanol under microwave irradiation has been performed to rapidly deprotect N-Cbz and N-Bn derivatives. The method is particularly suitable for the synthesis of short peptides and can also be carried out on supported molecules. The rapid cleavage of chiral molecules derived from (S)-1-phenylethylamine can be very useful for asymmetric synthesis of nitrogen containing compounds. (C) 2001 Elsevier Science Ltd. All rights reserved.
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https://hdl.handle.net/11365/30719
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