[GRAPHICS] beta -Lactams were prepared on solid phase starting from serine, threonine, or other beta -hydroxyacids derived from naturally occurring amino acids and a resin bound hydroxylamine, The ring closure was carried out under mitsunobu conditions. The amino group present on the beta -lactam was used to assemble a short peptide. After a reductive cleavage with SmI2, beta -lactam-containing peptides were obtained.

M. M., M., & Taddei, M. (2001). Solid-phase synthesis of beta-lactams via the Miller hydroxamate approach. ORGANIC LETTERS, 3, 337-340 [10.1021/ol006779z].

Solid-phase synthesis of beta-lactams via the Miller hydroxamate approach

TADDEI, MAURIZIO
2001

Abstract

[GRAPHICS] beta -Lactams were prepared on solid phase starting from serine, threonine, or other beta -hydroxyacids derived from naturally occurring amino acids and a resin bound hydroxylamine, The ring closure was carried out under mitsunobu conditions. The amino group present on the beta -lactam was used to assemble a short peptide. After a reductive cleavage with SmI2, beta -lactam-containing peptides were obtained.
M. M., M., & Taddei, M. (2001). Solid-phase synthesis of beta-lactams via the Miller hydroxamate approach. ORGANIC LETTERS, 3, 337-340 [10.1021/ol006779z].
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11365/30634
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