[GRAPHICS] beta -Lactams were prepared on solid phase starting from serine, threonine, or other beta -hydroxyacids derived from naturally occurring amino acids and a resin bound hydroxylamine, The ring closure was carried out under mitsunobu conditions. The amino group present on the beta -lactam was used to assemble a short peptide. After a reductive cleavage with SmI2, beta -lactam-containing peptides were obtained.
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|Titolo:||Solid-phase synthesis of beta-lactams via the Miller hydroxamate approach|
|Citazione:||M. M., M., & Taddei, M. (2001). Solid-phase synthesis of beta-lactams via the Miller hydroxamate approach. ORGANIC LETTERS, 3, 337-340.|
|Appare nelle tipologie:||1.1 Articolo in rivista|
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