Thirty-seven patients with stage I-II Hodgkin's disease and massive mediastinal involvement, observed between June 1981 and November 1989, underwent combined modality treatment. This treatment included: 3 cycles of mechlorethamine, vincristine, procarbazine, and prednisone followed by mantle-field irradiation, and subsequently by 3 additional cycles of doxorubicin, bleomycin, vinblastine, and dacarbazine. Thirty-five (95%) patients achieved complete responses and only 2 (5%) had partial responses. All the complete responders are living and relapse-free at a median follow-up of 62 months; no major toxic reactions were recorded. These data suggest, as did those of other studies, that combined modality therapy is superior to either radiotherapy or chemotherapy alone for patients in stage I-II with bulky disease, especially in the mediastinum. In fact, in these particular patients, if adequately treated with a combination of chemotherapy and radiotherapy, the role of massive mediastinal involvement as a poor prognostic factor appears to be less significant.

Zinzani, P.l., Mazzap, ., Gherlinzoni, F., Bocchia, M., Fiacchini, M., Bendandi, M., et al. (1992). Massive mediastinal involvment in stage I-II Hodgkin’s disease: response to combined modality treatment. LEUKEMIA & LYMPHOMA, 8, 81-85.

Massive mediastinal involvment in stage I-II Hodgkin’s disease: response to combined modality treatment.

BOCCHIA, MONICA;
1992

Abstract

Thirty-seven patients with stage I-II Hodgkin's disease and massive mediastinal involvement, observed between June 1981 and November 1989, underwent combined modality treatment. This treatment included: 3 cycles of mechlorethamine, vincristine, procarbazine, and prednisone followed by mantle-field irradiation, and subsequently by 3 additional cycles of doxorubicin, bleomycin, vinblastine, and dacarbazine. Thirty-five (95%) patients achieved complete responses and only 2 (5%) had partial responses. All the complete responders are living and relapse-free at a median follow-up of 62 months; no major toxic reactions were recorded. These data suggest, as did those of other studies, that combined modality therapy is superior to either radiotherapy or chemotherapy alone for patients in stage I-II with bulky disease, especially in the mediastinum. In fact, in these particular patients, if adequately treated with a combination of chemotherapy and radiotherapy, the role of massive mediastinal involvement as a poor prognostic factor appears to be less significant.
Zinzani, P.l., Mazzap, ., Gherlinzoni, F., Bocchia, M., Fiacchini, M., Bendandi, M., et al. (1992). Massive mediastinal involvment in stage I-II Hodgkin’s disease: response to combined modality treatment. LEUKEMIA & LYMPHOMA, 8, 81-85.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11365/30448
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