In this study we compared the diagnostic power of NCI to that of fractal geometry applied, at transmission electron microscopy level, as a tool to analyze the nuclear contour of lymphoid cells. The resulting mean D was always greater than the topological dimension (P<0.001) and the coefficient of determination of the linear fits had R2 value >0.95, showing the fractal approach appropriated (the mean ranges of scales for which linear log-log plot were found were between 100 and 700 nm). Both D and NCI were found to be significantly higher in MF (D=1.21+0.03; median =1.22; range 1.16-1.28 NCI=7.6+0.6; median =7.4; range 6.7-8.2) than in CD (D=1.11+ 0.02: median=1.11; range 1.05-1.14; NCI= 6.1+0.4; median=5.8; range 5.6-7.3) (Fig. 2, P<0.001). D significantly differed between nuclei showing NCI<7 (D=1.09+0.02, #=705) and nuclei with NCI>7 (D=1.19+0.02; #=520) (P<0.001). A significant positive correlation was found between D and NCI (r=0.75, P<0.001). The variance of D values was three times lower than that of NCI values (MF: 2.5 vs. 8%; CD: 1.9 vs. 6.9%, PB/0.01, PB/0.01, respectively). We suggest that fractal analysis could be an additional tool in the challenging differential diagnosis between benign dermatitis and early stage MF.
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|Titolo:||Differential diagnosis between mycosis fungoides and chronic dermatitis by fractal analysis.|
|Citazione:||Bianciardi, G., Miracco, C., De Santi, M.m., & Luzi, P. (2003). Differential diagnosis between mycosis fungoides and chronic dermatitis by fractal analysis. JOURNAL OF DERMATOLOGICAL SCIENCE, 33, 184-186.|
|Appare nelle tipologie:||1.1 Articolo in rivista|