A membrane system consisting of poly(acrylic acid)-grafted porous cellulose film and glucose oxidase was synthesized for insulin delivery in response to glucose concentration. The principle of this system is based on the conformational change of the graft chains in response to pH. At neutral pH in the absence of glucose, the carboxylate groups of poly(acrylic acid) grafts were negatively charged. Repulsion between negative charges made the polymer chains extend and closed the pores of the membrane. Glucose oxidase catalyzed the oxidation of glucose to gluconic acid which, in turn, protonated the carboxylate groups on the graft membrane. A reduced electrostatic repulsion between the poly(acrylic acid) side chains made the graft chains coil-like and opened the pores of the membrane to insulin. © 1989.
Casolaro, M., Imanishi, Y., Ito, Y., Kono, K. (1989). An insulin-releasing system that is responsive to glucose. JOURNAL OF CONTROLLED RELEASE, 10(2), 195-203 [10.1016/0168-3659(89)90063-1].
An insulin-releasing system that is responsive to glucose
Casolaro, Mario;
1989-01-01
Abstract
A membrane system consisting of poly(acrylic acid)-grafted porous cellulose film and glucose oxidase was synthesized for insulin delivery in response to glucose concentration. The principle of this system is based on the conformational change of the graft chains in response to pH. At neutral pH in the absence of glucose, the carboxylate groups of poly(acrylic acid) grafts were negatively charged. Repulsion between negative charges made the polymer chains extend and closed the pores of the membrane. Glucose oxidase catalyzed the oxidation of glucose to gluconic acid which, in turn, protonated the carboxylate groups on the graft membrane. A reduced electrostatic repulsion between the poly(acrylic acid) side chains made the graft chains coil-like and opened the pores of the membrane to insulin. © 1989.
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https://hdl.handle.net/11365/30395
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