The synthesis of a series of novel alpha-amino acids based on the nucleophilic substitution of protected 2-amino-4-bromobutanoic acid (1) is described. Basic, acidic or neutral amino acids can be obtained; chimerical amino acids carrying a coenzyme type structure in the side chain, multifunctional amino acids for the synthesis of cross-linked peptides or dendrimers and conformationally constrained peptides can also be obtained. (C) 1998 Elsevier Science Ltd. ALI rights reserved.
Ciapetti, P., Mann, A., Shoenfelder, A., Taddei, M. (1998). Nucleophilic substitution of protected 2-amino-4-butanoic acid. An easy route to exotic amino acids and conformationally constrained peptides. TETRAHEDRON LETTERS, 39(22), 3843-3846 [10.1016/S0040-4039(98)00628-5].
Nucleophilic substitution of protected 2-amino-4-butanoic acid. An easy route to exotic amino acids and conformationally constrained peptides
Taddei, Maurizio
1998-01-01
Abstract
The synthesis of a series of novel alpha-amino acids based on the nucleophilic substitution of protected 2-amino-4-bromobutanoic acid (1) is described. Basic, acidic or neutral amino acids can be obtained; chimerical amino acids carrying a coenzyme type structure in the side chain, multifunctional amino acids for the synthesis of cross-linked peptides or dendrimers and conformationally constrained peptides can also be obtained. (C) 1998 Elsevier Science Ltd. ALI rights reserved.
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https://hdl.handle.net/11365/30380
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