The epithelium associated with the lymphoid follicles of Peyer's patches differs from the villi epithelium by the presence of M cells. The main function of these cells is to take up antigens (inert material, viruses and bacteria) from the intestinal lumen. The M cells are able to internalize various different gram-negative bacteria. In order to show the M cells ability to interact and take up a gram-positive bacterium, we exposed rabbit Peyer's patches to Streptococcus pneumoniae R36a. Using the isolated ileal loop technique, Peyer's patches were incubated with a bacterial suspension for varying periods (15, 30, 60, 100 minutes). The bacteria were found outside and inside the M cells. The internalized streptococci could be found in the M cell cytoplasm, in the cytoplasmic "pockets" and inside the intraepithelial lymphoid cells. The finding of internalized bacteria with their damaged walls suggests the possibility that M cells are able to modify internalized antigens in the same way as the antigen presenting cells.

Regoli, M., Borghesi, C., Bertelli, E., & Nicoletti, C. (1995). Uptake of a Gram-positive bacterium (Streptococcus pneumoniae R36a) by the M cells of rabbit Peyer's patches. ANNALS OF ANATOMY, 177(2), 119-124 [10.1016/S0940-9602(11)80057-9].

Uptake of a Gram-positive bacterium (Streptococcus pneumoniae R36a) by the M cells of rabbit Peyer's patches

REGOLI, MARI';BERTELLI, EUGENIO;
1995

Abstract

The epithelium associated with the lymphoid follicles of Peyer's patches differs from the villi epithelium by the presence of M cells. The main function of these cells is to take up antigens (inert material, viruses and bacteria) from the intestinal lumen. The M cells are able to internalize various different gram-negative bacteria. In order to show the M cells ability to interact and take up a gram-positive bacterium, we exposed rabbit Peyer's patches to Streptococcus pneumoniae R36a. Using the isolated ileal loop technique, Peyer's patches were incubated with a bacterial suspension for varying periods (15, 30, 60, 100 minutes). The bacteria were found outside and inside the M cells. The internalized streptococci could be found in the M cell cytoplasm, in the cytoplasmic "pockets" and inside the intraepithelial lymphoid cells. The finding of internalized bacteria with their damaged walls suggests the possibility that M cells are able to modify internalized antigens in the same way as the antigen presenting cells.
Regoli, M., Borghesi, C., Bertelli, E., & Nicoletti, C. (1995). Uptake of a Gram-positive bacterium (Streptococcus pneumoniae R36a) by the M cells of rabbit Peyer's patches. ANNALS OF ANATOMY, 177(2), 119-124 [10.1016/S0940-9602(11)80057-9].
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11365/29770
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