The infant stage of rat development is a very important period for potential correction of adverse consequences produced by negative prenatal events. However the age limit for this correction needs to be investigated. The last prenatal and first two weeks after birth are "critical" for maturation of the nociceptive and emotional systems. Clinical observations suggest a correlation between persistent pain response and emotional behavior. In infant male rats of different ages, we studied indices of the inflammatory pain response (the number of flexes+shakes in the formalin test), depression-related behavior (immobility in the forced swim test) and the relations between them, as well as the effects of prenatal stress on these indices. Furthermore, we assessed the trend of body weight and the relations between body weight and the depression- and pain-related behaviors. We demonstrate heterogeneity of the infant stage: control prenatally non-stressed rat pups showed significantly lower immobility at 7 days of age than at 10 days; prenatal stress caused an increase of immobility and the number of flexes+shakes in 7-8-day-old pups but not in 10-11-day-olds. These findings should be taken into account in the treatment of abnormalities of emotional and inflammatory pain-related behaviors produced by prenatal stressful events. The present data and our previous findings indicate that the deficiency of body weight in prenatally stressed newborns may predict the development of abnormalities in inflammatory pain-related responses during postnatal ontogeny.
|Titolo:||Heterogeneity of the infant stage of rat development: inflammatory pain response, depression-related behavior, and effects of prenatal stress|
|Appare nelle tipologie:||1.1 Articolo in rivista|