BACKGROUND: Resection line involvement has been indicated as an important prognostic factor for gastric cancer. Its late detection renders the choice of treatment difficult for surgeons. MATERIALS AND METHODS: We describe the multicenter experience of a group of 11 patients with early gastric carcinoma (EGC) and positive resection confirmed at histological examination who did not undergo surgical retreatment for reasons of associated disease, surgical considerations on duodenal stump, or patient refusal. RESULTS: The gastric margin was involved in 4 patients, and 7 patients had duodenal resection line involvement. No surgical complications or postoperative deaths were observed. Five and 8-year survival was 100% and 86%, respectively. The only patient who relapsed did not have lymph node involvement and died from liver metastases, without local recurrence. CONCLUSIONS: It is sometimes difficult to accurately define the resection line in gastric cancer surgery, especially in the early stages of disease, but because of the strongly negative prognostic value of an infiltrated margin, frozen sections are recommended if neoplastic invasion is suspected and a new resection is always recommended if possible. Nevertheless, the good prognosis of resected EGC patients with resection line involvement must be considered before submitting patients with associated diseases to radical surgical retreatment.
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|Titolo:||Does resection line involvement affect prognosis in early gastric cancer patients? An Italian multicentric study|
|Rivista:||WORLD JOURNAL OF SURGERY|
|Citazione:||Morgagni, P., Garcea, D., Marrelli, D., DE MANZONI, G., Natalini, G., Kurihara, H., et al. (2006). Does resection line involvement affect prognosis in early gastric cancer patients? An Italian multicentric study. WORLD JOURNAL OF SURGERY, 30(4), 585-589.|
|Appare nelle tipologie:||1.1 Articolo in rivista|