Methadone displaces [3H]imipramine from its binding sites in rat brain and platelets with an IC50 of 10-6 M and 4 × 10-7 M, respectively. These IC50 values are similar to the plasma concentrations of methadone found in former heroin addicts on methadone maintenance therapy. A possible antidepressant action of methadone is suggested. © 1982.
De Montis, M.G., Devoto, P., Tagliamonte, A. (1982). Possible antidepressant activity of methadone. EUROPEAN JOURNAL OF PHARMACOLOGY, 79(1-2), 145-146 [10.1016/0014-2999(82)90587-8].
Possible antidepressant activity of methadone
De Montis, M. G.;
1982-01-01
Abstract
Methadone displaces [3H]imipramine from its binding sites in rat brain and platelets with an IC50 of 10-6 M and 4 × 10-7 M, respectively. These IC50 values are similar to the plasma concentrations of methadone found in former heroin addicts on methadone maintenance therapy. A possible antidepressant action of methadone is suggested. © 1982.
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