A microdilution test measuring imipenem MICs in the presence or absence of a mixture of EDTA plus 1,10-phenanthroline was developed and tested on 190 Pseudomonas aeruginosa isolates, including 18 VIM-and 4 IMP-type metallo-β-lactamase (MBL) producers. The chelator mixture reduced by fourfold or more the imipenem MICs for MBL producers, while a lower effect or no effect was usually observed with MBL nonproducers.
Migliavacca, R., Docquier, J.D., Mugnaioli, C., Amicosante, G., Daturi, R., Lee, K., et al. (2002). Simple microdilution test for detection of metallo-beta-lactamase production in Pseudomonas aeruginosa. JOURNAL OF CLINICAL MICROBIOLOGY, 40(11), 4388-4390 [10.1128/JCM.40.11.4388-4390.2002].
Simple microdilution test for detection of metallo-beta-lactamase production in Pseudomonas aeruginosa
DOCQUIER J. D.;
2002-01-01
Abstract
A microdilution test measuring imipenem MICs in the presence or absence of a mixture of EDTA plus 1,10-phenanthroline was developed and tested on 190 Pseudomonas aeruginosa isolates, including 18 VIM-and 4 IMP-type metallo-β-lactamase (MBL) producers. The chelator mixture reduced by fourfold or more the imipenem MICs for MBL producers, while a lower effect or no effect was usually observed with MBL nonproducers.
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https://hdl.handle.net/11365/2884
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