B-cell chronic lymphocytic leukaemia (B-CLL) is characterized by a high frequency of infections, including those of viral aetiology. Previous reports have demonstrated a specific immunologic response to influenza virus vaccine in B-CLL patients with normal IgG levels. In this study, we have evaluated different immunophenotypically defined B and T cell subsets in 18 B-CLL patients before immunization with killed-influenza-virus vaccine. A correlation between immunological response to vaccination and both absolute numbers of CD4+/CD45RA+ naive T cells and CD5- B cells was found. These data may suggest a supporting role of the CD4+-/CD45RA+ T cell subset in the specific antibody response to vaccination with influenza virus vaccine in B-CLL patients.
Marotta, G., Bucalossi, A., Galieni, P., Bigazzi, C., Nuti, S., Valenzin, P.E., et al. (1998). CD4+/CD45RA+ “naive” T cells and immunological response to influenza virus vaccine in B-cell chromnic lymphocitic leukemia patients. ACTA HAEMATOLOGICA, 99, 18-21 [10.1159/000040709].
CD4+/CD45RA+ “naive” T cells and immunological response to influenza virus vaccine in B-cell chromnic lymphocitic leukemia patients
VALENZIN P. E.;BOCCHIA M.;LAURIA F.
1998-01-01
Abstract
B-cell chronic lymphocytic leukaemia (B-CLL) is characterized by a high frequency of infections, including those of viral aetiology. Previous reports have demonstrated a specific immunologic response to influenza virus vaccine in B-CLL patients with normal IgG levels. In this study, we have evaluated different immunophenotypically defined B and T cell subsets in 18 B-CLL patients before immunization with killed-influenza-virus vaccine. A correlation between immunological response to vaccination and both absolute numbers of CD4+/CD45RA+ naive T cells and CD5- B cells was found. These data may suggest a supporting role of the CD4+-/CD45RA+ T cell subset in the specific antibody response to vaccination with influenza virus vaccine in B-CLL patients.
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https://hdl.handle.net/11365/2874
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