The measles virus proteins haemagglutinin (HA) and fusion protein (F), which together mediate attachment and penetration of the virus in the host cell and can elicit production of neutralising antibodies in the course of natural infection were expressed in the vaccine vector Streptococcus gordonii, a Gram-positive bacterium normally present in the human oral cavity. HA and F were expressed as fusion proteins attached to the bacterial surface, and were both found to be immunogenic when the recombinant S. gordonii were inoculated subcutaneously in mice.
Maggi, T., Oggioni, M.R., Medaglini, D., BIANCHI BANDINELLI, M.L., Soldateschi, D., Wiesmüller, K.H., et al. (2000). Expression of measles virus antigens in Streptococcus gordonii. NEW MICROBIOLOGICA, 23(2), 119-128.
Expression of measles virus antigens in Streptococcus gordonii
MEDAGLINI, DONATA;BIANCHI BANDINELLI, MARIA LETIZIA;VALENSIN, PIER EGISTO;POZZI, GIANNI
2000-01-01
Abstract
The measles virus proteins haemagglutinin (HA) and fusion protein (F), which together mediate attachment and penetration of the virus in the host cell and can elicit production of neutralising antibodies in the course of natural infection were expressed in the vaccine vector Streptococcus gordonii, a Gram-positive bacterium normally present in the human oral cavity. HA and F were expressed as fusion proteins attached to the bacterial surface, and were both found to be immunogenic when the recombinant S. gordonii were inoculated subcutaneously in mice.
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https://hdl.handle.net/11365/28198
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