The perikarya of the dopaminergic and non-dopaminergic neurons contained in the substantia nigra were selectively destroyed by a proper, local injection of 6-hydroxydopamine or kainic acid, respectively. Both lesions resulted in a marked decrease of the nigral GABA-binding sites. The effect of 6-hydroxydopamine was restricted to the high affinity receptors, while kainic acid specifically decreased the low affinity ones.
De Montis, M.G., Olianas, M.C., Mulas, G., Lloyd, K.G., Tagliamonte, A. (1981). GABA receptors distribution in rat substantia nigra. NEUROSCIENCE LETTERS, 23(3), 257-261 [10.1016/0304-3940(81)90007-0].
GABA receptors distribution in rat substantia nigra
De Montis, M. G.;Tagliamonte, A.
1981-01-01
Abstract
The perikarya of the dopaminergic and non-dopaminergic neurons contained in the substantia nigra were selectively destroyed by a proper, local injection of 6-hydroxydopamine or kainic acid, respectively. Both lesions resulted in a marked decrease of the nigral GABA-binding sites. The effect of 6-hydroxydopamine was restricted to the high affinity receptors, while kainic acid specifically decreased the low affinity ones.
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https://hdl.handle.net/11365/27452
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