Dopamine (DA) D1 receptors and the response of adenylyl cyclase (AC) to dopamine stimulation were studied in the limbic areas and the caudate-putamen of Sardinian ethanol-preferring (SP), Sardinian ethanol-non-preferring (SNP) and Wistar unselected (UW) rats. SP rats exhibited a significantly lower number of D1 receptors, measured using [3H]SCH 23390 binding, and a decreased response to DA stimulation than SNP and UW animals. Since SP rats have also a lower number of D2 receptors, the results suggest that an altered dopaminergic transmission may underlie their innate alcohol preference.

DE MONTIS, M.G., Gambarana, C., Gessa, G.L., Meloni, D., Tagliamonte, A., & Stefanini, E. (1993). Reduced [3H]SCH 23390 binding and DA sensitive adenylyl cyclase in the limbic system of ethanol preferring rats. ALCOHOL AND ALCOHOLISM, 28(4), 397-400.

Reduced [3H]SCH 23390 binding and DA sensitive adenylyl cyclase in the limbic system of ethanol preferring rats

DE MONTIS, M. G.;GAMBARANA, C.;TAGLIAMONTE, A.;
1993

Abstract

Dopamine (DA) D1 receptors and the response of adenylyl cyclase (AC) to dopamine stimulation were studied in the limbic areas and the caudate-putamen of Sardinian ethanol-preferring (SP), Sardinian ethanol-non-preferring (SNP) and Wistar unselected (UW) rats. SP rats exhibited a significantly lower number of D1 receptors, measured using [3H]SCH 23390 binding, and a decreased response to DA stimulation than SNP and UW animals. Since SP rats have also a lower number of D2 receptors, the results suggest that an altered dopaminergic transmission may underlie their innate alcohol preference.
DE MONTIS, M.G., Gambarana, C., Gessa, G.L., Meloni, D., Tagliamonte, A., & Stefanini, E. (1993). Reduced [3H]SCH 23390 binding and DA sensitive adenylyl cyclase in the limbic system of ethanol preferring rats. ALCOHOL AND ALCOHOLISM, 28(4), 397-400.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11365/2741
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