Dopamine (DA) D1 receptors and the response of adenylyl cyclase (AC) to dopamine stimulation were studied in the limbic areas and the caudate-putamen of Sardinian ethanol-preferring (SP), Sardinian ethanol-non-preferring (SNP) and Wistar unselected (UW) rats. SP rats exhibited a significantly lower number of D1 receptors, measured using [3H]SCH 23390 binding, and a decreased response to DA stimulation than SNP and UW animals. Since SP rats have also a lower number of D2 receptors, the results suggest that an altered dopaminergic transmission may underlie their innate alcohol preference.
DE MONTIS, M.G., Gambarana, C., Gessa, G.L., Meloni, D., Tagliamonte, A., Stefanini, E. (1993). Reduced [3H]SCH 23390 binding and DA sensitive adenylyl cyclase in the limbic system of ethanol preferring rats. ALCOHOL AND ALCOHOLISM, 28(4), 397-400.
Reduced [3H]SCH 23390 binding and DA sensitive adenylyl cyclase in the limbic system of ethanol preferring rats
DE MONTIS, M. G.;GAMBARANA, C.;TAGLIAMONTE, A.;
1993-01-01
Abstract
Dopamine (DA) D1 receptors and the response of adenylyl cyclase (AC) to dopamine stimulation were studied in the limbic areas and the caudate-putamen of Sardinian ethanol-preferring (SP), Sardinian ethanol-non-preferring (SNP) and Wistar unselected (UW) rats. SP rats exhibited a significantly lower number of D1 receptors, measured using [3H]SCH 23390 binding, and a decreased response to DA stimulation than SNP and UW animals. Since SP rats have also a lower number of D2 receptors, the results suggest that an altered dopaminergic transmission may underlie their innate alcohol preference.
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https://hdl.handle.net/11365/2741
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