2-Dibenzylamino-5-oxopentanoic acid benzyl ester has been obtained in good yields by complete benzylation of L-glutamic acid in NaOH and Na2CO3, selective reduction of the gamma-ester into alcohol with DIBAL and further transformation into aldehyde using Swern oxidation. The overall three-step procedure from Glu gave aldehyde in 49% yield.
Rodriquez, M., Taddei, M. (2005). A simple procedure for the transformation of L- Glutamic acid into the corresponding g-aldehyde. SYNTHESIS(3), 493-496 [10.1055/s-2004-834865].
A simple procedure for the transformation of L- Glutamic acid into the corresponding g-aldehyde
TADDEI M.
2005-01-01
Abstract
2-Dibenzylamino-5-oxopentanoic acid benzyl ester has been obtained in good yields by complete benzylation of L-glutamic acid in NaOH and Na2CO3, selective reduction of the gamma-ester into alcohol with DIBAL and further transformation into aldehyde using Swern oxidation. The overall three-step procedure from Glu gave aldehyde in 49% yield.
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https://hdl.handle.net/11365/2724
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