OBJECTIVE: The aim of our randomized, controlled trial was to verify the effect of folic acid supplementation on homocysteine levels in postmenopausal women. STUDY DESIGN: Thirty-six women were divided randomly into 2 groups as follows: a placebo group (n = 18) and a group receiving 500 μg folic acid per day for 4 weeks (n = 18). To assess concentrations of plasma homocysteine, venous blood samples were taken on enrollment and after 4 weeks of treatment. RESULTS: Mean plasma homocysteine levels were 10.9 ± 2.7 μmol/L in the placebo group and 7.8 ± 2.35 μmol/L (P < .01) in the group receiving 500 μg folic acid per day for 4 weeks. The thirds (referred to as tertiles) of women with the highest baseline homocysteine plasma levels showed the greatest reduction in homocysteine, with a mean decrease of 4.35 μmol/L (32%; P < .01), in comparison with a decrease of 3.35 μmol/L (29%; P < .01) in the middle tertile and 1.3 μmol/L (22.4%; P = .09) in the lower tertile. CONCLUSIONS: The results show that low doses of folic acid are associated with a significant reduction in plasma concentrations of homocysteine. The highest initial levels of homocysteine showed the most important reduction after therapy.

De Leo, V., La Marca, A., Morgante, G., Ciani, F., Zammarchi, E., & Setacci, C. (2000). Low-dose folic acid supplementation reduces plasma levels of the cardiovascular risk factor homocysteine in postmenopausal women. AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 183(4), 945-947 [10.1067/mob.2000.106345].

Low-dose folic acid supplementation reduces plasma levels of the cardiovascular risk factor homocysteine in postmenopausal women

De Leo, V.;Morgante, G.;Setacci, C.
2000

Abstract

OBJECTIVE: The aim of our randomized, controlled trial was to verify the effect of folic acid supplementation on homocysteine levels in postmenopausal women. STUDY DESIGN: Thirty-six women were divided randomly into 2 groups as follows: a placebo group (n = 18) and a group receiving 500 μg folic acid per day for 4 weeks (n = 18). To assess concentrations of plasma homocysteine, venous blood samples were taken on enrollment and after 4 weeks of treatment. RESULTS: Mean plasma homocysteine levels were 10.9 ± 2.7 μmol/L in the placebo group and 7.8 ± 2.35 μmol/L (P < .01) in the group receiving 500 μg folic acid per day for 4 weeks. The thirds (referred to as tertiles) of women with the highest baseline homocysteine plasma levels showed the greatest reduction in homocysteine, with a mean decrease of 4.35 μmol/L (32%; P < .01), in comparison with a decrease of 3.35 μmol/L (29%; P < .01) in the middle tertile and 1.3 μmol/L (22.4%; P = .09) in the lower tertile. CONCLUSIONS: The results show that low doses of folic acid are associated with a significant reduction in plasma concentrations of homocysteine. The highest initial levels of homocysteine showed the most important reduction after therapy.
De Leo, V., La Marca, A., Morgante, G., Ciani, F., Zammarchi, E., & Setacci, C. (2000). Low-dose folic acid supplementation reduces plasma levels of the cardiovascular risk factor homocysteine in postmenopausal women. AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 183(4), 945-947 [10.1067/mob.2000.106345].
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11365/27178
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