The lymphatic route. IV.Pharmacokinetics of human recombinant interferon alpha2 and natural interferon beta administered intradermally in rabbits

We have evaluated the feasibility of administering human recombinant interferon α2 and human natural interferon β via the intradermal route with an air-pressure injector in the rabbit model. This is the first report showing pharmacokinetic parameters after intradermal administration of interferon. The prolonged permanence of circulating interferon α2 and its excellent bioavailability make this route an attractive one to be tested in patients because it may increase the therapeutic index of IFN. On the other hand. this route seems less practical for IFN β for reasons probably connected with inactivation and/or scarce absorption of this drug from the skin.