A modified Mukaiyama reagent was prepared on a PS-DVB resin. This reagent was used for the preparation of β-lactams, using the Staudinger reaction. The products were obtained by generating the ketene from a carboxylic acid under sonication with the resin followed by reaction with the imine. Excess of the imine was removed by reduction followed by acid scavenging.
Donati, D., Morelli, C., Porcheddu, A., Taddei, M. (2004). A new polymer supported reagent for the synthesis of beta-lactams in solution. JOURNAL OF ORGANIC CHEMISTRY, 69(26), 9316-9318 [10.1021/jo048400i].
A new polymer supported reagent for the synthesis of beta-lactams in solution
Donati, Donato;Morelli, Costanza;Taddei, Maurizio
2004-01-01
Abstract
A modified Mukaiyama reagent was prepared on a PS-DVB resin. This reagent was used for the preparation of β-lactams, using the Staudinger reaction. The products were obtained by generating the ketene from a carboxylic acid under sonication with the resin followed by reaction with the imine. Excess of the imine was removed by reduction followed by acid scavenging.
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https://hdl.handle.net/11365/2614
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