Novel strategies are required to provide rapid vaccine coverage in the event of an influenza pandemic. A phase I/II dose finding/formulation study was performed with a whole-virus H5N1 clade 1 A/Vietnam vaccine (2-dose priming regimen) to evaluate safety and immunogenicity. Seventy-seven of 141 subjects in this study received a booster (12-17 months after priming) with a 7.5-microg dose of a clade 2.1 A/Indonesia vaccine. The prime-boost regimen resulted in antibody responses against clade 1, 2.1, 2.2, and 2.3 viruses that were significantly higher than those after the priming regimen. These findings demonstrate that a prime-boost regimen may alleviate vaccine supply constraints in a pandemic.

Ehrlich, H.J., Müller, M., Fritsch, S., Zeitlinger, M., Berezuk, G., Löw-Baselli, A., et al. (2009). A Cell Culture (Vero)–Derived H5N1 Whole-Virus Vaccine Induces Cross-Reactive Memory Responses. THE JOURNAL OF INFECTIOUS DISEASES, 200(7), 1113-1118 [10.1086/605608].

A Cell Culture (Vero)–Derived H5N1 Whole-Virus Vaccine Induces Cross-Reactive Memory Responses

Montomoli E.;
2009-01-01

Abstract

Novel strategies are required to provide rapid vaccine coverage in the event of an influenza pandemic. A phase I/II dose finding/formulation study was performed with a whole-virus H5N1 clade 1 A/Vietnam vaccine (2-dose priming regimen) to evaluate safety and immunogenicity. Seventy-seven of 141 subjects in this study received a booster (12-17 months after priming) with a 7.5-microg dose of a clade 2.1 A/Indonesia vaccine. The prime-boost regimen resulted in antibody responses against clade 1, 2.1, 2.2, and 2.3 viruses that were significantly higher than those after the priming regimen. These findings demonstrate that a prime-boost regimen may alleviate vaccine supply constraints in a pandemic.
Ehrlich, H.J., Müller, M., Fritsch, S., Zeitlinger, M., Berezuk, G., Löw-Baselli, A., et al. (2009). A Cell Culture (Vero)–Derived H5N1 Whole-Virus Vaccine Induces Cross-Reactive Memory Responses. THE JOURNAL OF INFECTIOUS DISEASES, 200(7), 1113-1118 [10.1086/605608].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11365/25704
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