Primary hepatic epithelioid hemangioendothelioma (HEH) is a rare, low-grade malignant neoplasm of endothelial origin, with an unpredictable clinical course and prognosis. No standard therapeutic strategies are still available for HEH, due to the infrequency of the disease and to its variable natural history that limit the identification of the most effective treatment. In the absence of metastatic disease, surgical resection or liver transplantation represent the treatment of choice for HEH, while several antineoplastic agents have been proposed in the presence of metastatic nonresectable disesase. Herein, we describe the biological characterization and the clinical course of a primary HEH progressively responsive to treatment with intermediate doses of interferon-alpha (IFN)-alpha2a. Furthermore, based on the newly-identified expression of endoglin (CD105) on HEH, we discuss the clinical potential of novel anti-angiogenetic approaches to the disease.
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|Titolo:||Primary hepatic epithelioid hemangioendothelioma progressively responsive to interferon-alpha: is there room for novel anti-angiogenetic treatments?|
|Rivista:||JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH|
|Citazione:||Calabrò, L., DI GIACOMO, A.m., Altomonte, M., Fonsatti, E., Mazzei, M.A., Volterrani, L., et al. (2007). Primary hepatic epithelioid hemangioendothelioma progressively responsive to interferon-alpha: is there room for novel anti-angiogenetic treatments?. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 26(1), 145-150.|
|Appare nelle tipologie:||1.1 Articolo in rivista|