The absorption of both human lymphoblastoid interferon α and natural interferon β from the large intestine has been evaluated in the rat. We have shown that the addition of Labrafil R.M.1944 to the citrate buffer containing interferon α favours its absorption through the enteric mucosa in a significant way while it has practically no beneficial effect for interferon β. It appears worthwhile to pursue this line of investigation because the enteric route may enlarge the field of therapeutic application of interferon.
Bocci, V., Corradeschi, F., Naldini, A., Lencioni, E. (1986). Enteric absorption of human interferons α and β in the rat. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 34(1-2), 111-114 [10.1016/0378-5173(86)90016-5].
Enteric absorption of human interferons α and β in the rat
Bocci, V.;Corradeschi, F.;Naldini, A.;Lencioni, E.
1986-01-01
Abstract
The absorption of both human lymphoblastoid interferon α and natural interferon β from the large intestine has been evaluated in the rat. We have shown that the addition of Labrafil R.M.1944 to the citrate buffer containing interferon α favours its absorption through the enteric mucosa in a significant way while it has practically no beneficial effect for interferon β. It appears worthwhile to pursue this line of investigation because the enteric route may enlarge the field of therapeutic application of interferon.
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https://hdl.handle.net/11365/25074
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