Hypericum perforatum is one of the oldest and most experimentally and clinically studied herbal drugs. In this work, using HPLC/MS/MS, we investigated the chemical composition of the methanolic extract of the flowering tops of Oleum Hyperici, an ancient remedy obtained following the methodology reported in Deutsche Arzneibuch 6 (DAB). The chemical composition of Oleum Hyperici was very different from that of the crude drug, in which two new phloroglucinols were identified for the first time. The main components responsible for the activity (hyperforin and its derivatives, hypericin and its derivatives) were not found in the oil extract. The sun protection factor (SPF) for Oleum Hyperici was demonstrated to be low.

Miraldi, E., Biagi, M., & Giachetti, D. (2006). Chemical constituents and effect of topical application of Oleum Hyperici on skin sensitivity to simulated sun exposure. NATURAL PRODUCT COMMUNICATIONS, 1(3), 209-213 [10.1177/1934578x0600100307].

Chemical constituents and effect of topical application of Oleum Hyperici on skin sensitivity to simulated sun exposure

MIRALDI, E.;BIAGI, M.;GIACHETTI, D.
2006

Abstract

Hypericum perforatum is one of the oldest and most experimentally and clinically studied herbal drugs. In this work, using HPLC/MS/MS, we investigated the chemical composition of the methanolic extract of the flowering tops of Oleum Hyperici, an ancient remedy obtained following the methodology reported in Deutsche Arzneibuch 6 (DAB). The chemical composition of Oleum Hyperici was very different from that of the crude drug, in which two new phloroglucinols were identified for the first time. The main components responsible for the activity (hyperforin and its derivatives, hypericin and its derivatives) were not found in the oil extract. The sun protection factor (SPF) for Oleum Hyperici was demonstrated to be low.
Miraldi, E., Biagi, M., & Giachetti, D. (2006). Chemical constituents and effect of topical application of Oleum Hyperici on skin sensitivity to simulated sun exposure. NATURAL PRODUCT COMMUNICATIONS, 1(3), 209-213 [10.1177/1934578x0600100307].
File in questo prodotto:
File Dimensione Formato  
oleum2006.pdf

non disponibili

Tipologia: Post-print
Licenza: NON PUBBLICO - Accesso privato/ristretto
Dimensione 188.47 kB
Formato Adobe PDF
188.47 kB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11365/24802
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo