Objective: The pathogenesis and clinical significance of true umbilical cord knots remain controversial. Here, we tested the hypothesis of the presence of congenital oral mucosal changes in newborns with true umbilical cord knots. Study design: Seven consecutive infants with true umbilical cord knots and 50 gestational age- and sex-matched controls were enrolled. The proportion of oral frenulum abnormalities and the two-dimensional vascular network geometry [fractal dimension, D, at two scales: D(1–46), and D(1–15), with the relative LempelZiv complexity, (L-Z)], were analyzed. Results: Infants with true umbilical cord knots showed significantly higher proportions of mandibular frenulum agenesis compared to controls (p = 0.000006). The oral vascular networks of these infants exhibited a significantly higher D(1–46) and D(1–15) (p !0.0001, respectively), and higher L-Z values (p !0.0001) than control networks. . Conclusion: These findings indicate the presence of significant congenital oral mucosal changes in newborn infants with true umbilical cord knots, thus suggesting a previously unrecognized association between true umbilical cord knots and a subclinical extracellular matrix disorder.

DE FELICE, C., Bianciardi, G., Parrini, S., Laurini, R.N., Latini, G. (2004). Congenital oral mucosal abnormalities in true umbilical cord knots. BIOLOGY OF THE NEONATE, 86(1), 34-38 [10.1159/000077333].

Congenital oral mucosal abnormalities in true umbilical cord knots

G. BIANCIARDI;S. PARRINI;
2004-01-01

Abstract

Objective: The pathogenesis and clinical significance of true umbilical cord knots remain controversial. Here, we tested the hypothesis of the presence of congenital oral mucosal changes in newborns with true umbilical cord knots. Study design: Seven consecutive infants with true umbilical cord knots and 50 gestational age- and sex-matched controls were enrolled. The proportion of oral frenulum abnormalities and the two-dimensional vascular network geometry [fractal dimension, D, at two scales: D(1–46), and D(1–15), with the relative LempelZiv complexity, (L-Z)], were analyzed. Results: Infants with true umbilical cord knots showed significantly higher proportions of mandibular frenulum agenesis compared to controls (p = 0.000006). The oral vascular networks of these infants exhibited a significantly higher D(1–46) and D(1–15) (p !0.0001, respectively), and higher L-Z values (p !0.0001) than control networks. . Conclusion: These findings indicate the presence of significant congenital oral mucosal changes in newborn infants with true umbilical cord knots, thus suggesting a previously unrecognized association between true umbilical cord knots and a subclinical extracellular matrix disorder.
2004
DE FELICE, C., Bianciardi, G., Parrini, S., Laurini, R.N., Latini, G. (2004). Congenital oral mucosal abnormalities in true umbilical cord knots. BIOLOGY OF THE NEONATE, 86(1), 34-38 [10.1159/000077333].
File in questo prodotto:
File Dimensione Formato  
Biol neonate 2004.pdf

non disponibili

Tipologia: Abstract
Licenza: NON PUBBLICO - Accesso privato/ristretto
Dimensione 181.67 kB
Formato Adobe PDF
181.67 kB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11365/24732
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo