An array of tetrasubstituted pyrroles (and trisubstituted furans) was obtained using a simple three-step procedure. Functional homologation of a ��-ketoester with an aldehyde followed by oxidation gave a series of differently substituted 1,4-dicarbonyl compounds that can be rapidly cyclized with the Paal−Knorr procedure carried out under microwave irradiation.
Minetto, G., Raveglia, L., Taddei, M. (2004). Microwave-Assisted Paal−Knorr Reaction. A Rapid Approach to Substituted Pyrroles and Furans. ORGANIC LETTERS, 6(3), 389-392 [10.1021/ol0362820].
Microwave-Assisted Paal−Knorr Reaction. A Rapid Approach to Substituted Pyrroles and Furans
Minetto, Giacomo;Taddei, Maurizio
2004-01-01
Abstract
An array of tetrasubstituted pyrroles (and trisubstituted furans) was obtained using a simple three-step procedure. Functional homologation of a ��-ketoester with an aldehyde followed by oxidation gave a series of differently substituted 1,4-dicarbonyl compounds that can be rapidly cyclized with the Paal−Knorr procedure carried out under microwave irradiation.
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https://hdl.handle.net/11365/24606
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