Many strains of Vibrio cholerae produce a cytolysin (VCC) that forms oligomeric transmembrane pores responsible for vacuolization of several cell types in culture. Here we suggest that VCC could contribute to the T helper 2 (Th2) response seen in the natural infection; acting through TLR2, VCC enhances mast cells secretion of IL-4, IL-6 and TNF-alpha by 330-, 290- and 550-fold respectively. Moreover, VCC-induced cytokine production is dependent on increased cytosolic Ca(2+) and on the presence of the Src family kinases Lyn and Fyn, known to be required for FcepsilonRI-dependent activation of mast cells. These findings strongly suggest that VCC has a pro-inflammatory activity promoting a Th2-type immune profile

Arcidiacono, D., Odom, S., Frossi, B., Rivera, J., Rossi Paccani, S., Baldari, C.T., et al. (2008). The Vibrio cholerae cytolysin (VCC) promotes activation of mast cell (T helper 2) cytokine production. CELLULAR MICROBIOLOGY, 10, 899-907.

The Vibrio cholerae cytolysin (VCC) promotes activation of mast cell (T helper 2) cytokine production

Rossi Paccani, S.;Baldari, C. T.;
2008

Abstract

Many strains of Vibrio cholerae produce a cytolysin (VCC) that forms oligomeric transmembrane pores responsible for vacuolization of several cell types in culture. Here we suggest that VCC could contribute to the T helper 2 (Th2) response seen in the natural infection; acting through TLR2, VCC enhances mast cells secretion of IL-4, IL-6 and TNF-alpha by 330-, 290- and 550-fold respectively. Moreover, VCC-induced cytokine production is dependent on increased cytosolic Ca(2+) and on the presence of the Src family kinases Lyn and Fyn, known to be required for FcepsilonRI-dependent activation of mast cells. These findings strongly suggest that VCC has a pro-inflammatory activity promoting a Th2-type immune profile
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11365/24481
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