The assembly and maintenance of primary cilia, which orchestrate signaling pathways centrally implicated in cell proliferation, differentiation and migration, are ensured by multimeric protein particles in a process known as intraflagellar transport (IFT). It has recently been demonstrated that a number of IFT components are expressed in hematopoietic cells, which have no cilia. Here, we summarize data for an unexpected role of IFT proteins in immune synapse assembly and intracellular membrane trafficking in T lymphocytes, and discuss the hypothesis that the immune synapse could represent the functional homolog of the primary cilium in these cells.

Finetti, F., Rossi Paccani, S., Rosenbaum, J., Baldari, C. (2011). Intraflagellar transport: a new player at the immune synapse. TRENDS IN IMMUNOLOGY, 32(4), 139-145 [10.1016/j.it.2011.02.001].

Intraflagellar transport: a new player at the immune synapse.

Finetti, Francesca;Rossi Paccani, Silvia;Baldari, Cosima
2011-01-01

Abstract

The assembly and maintenance of primary cilia, which orchestrate signaling pathways centrally implicated in cell proliferation, differentiation and migration, are ensured by multimeric protein particles in a process known as intraflagellar transport (IFT). It has recently been demonstrated that a number of IFT components are expressed in hematopoietic cells, which have no cilia. Here, we summarize data for an unexpected role of IFT proteins in immune synapse assembly and intracellular membrane trafficking in T lymphocytes, and discuss the hypothesis that the immune synapse could represent the functional homolog of the primary cilium in these cells.
Finetti, F., Rossi Paccani, S., Rosenbaum, J., Baldari, C. (2011). Intraflagellar transport: a new player at the immune synapse. TRENDS IN IMMUNOLOGY, 32(4), 139-145 [10.1016/j.it.2011.02.001].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11365/24472