Non-pathogenic Gram-positive oral commensal bacteria expressing recombinant fusion proteins on their cell surface have been successfully used to raise both a mucosal and a systemic immune response to foreign antigens while colonizing the oropharynx. In this system, fusion-protein vaccines are delivered and anchored to the surface of a commensal, which occupies the mucosal niche invaded by a particular pathogen. Surface expression of these foreign proteins is achieved by exploiting the common mechanism employed by Gram-positive bacteria for translocating and anchoring proteins to the cell surface. The process offers a safe alternative to the use of engineered pathogens as live vaccine delivery vehicles.
Scheda prodotto non validato
Scheda prodotto in fase di analisi da parte dello staff di validazione
|Titolo:||Expression of foreign proteins on gram-positive commensal bacteria for mucosal vaccine delivery.|
|Rivista:||CURRENT OPINION IN BIOTECHNOLOGY|
|Citazione:||Fischetti, V.A., Medaglini, D., Oggioni, M., & Pozzi, G. (1993). Expression of foreign proteins on gram-positive commensal bacteria for mucosal vaccine delivery. CURRENT OPINION IN BIOTECHNOLOGY, 4(5), 603-610.|
|Appare nelle tipologie:||1.1 Articolo in rivista|
File in questo prodotto: