To evaluate the role of testosterone in pain modulation, we subcutaneously injected male and female rats with testosterone propionate (TP, 5 mg/kg in oil) or oil for 6 days; on the seventh day, all rats were subjected to the formalin test (10%, 50 microl). Behaviours were recorded in an open field (60 min). At the end of the formalin test, the rats were anaesthetized to collect blood from the abdominal aorta. Among the formalin-induced responses, licking was higher in females than males and was decreased by TP in females; jerking and flexing were only slightly affected by treatment. TP increased testosterone plasma levels in both sexes. These results indicate a role of testosterone in modulating formalin-induced responses. The effects appear to be different in males and females.

Aloisi, A.M., Ceccarelli, I., Fiorenzani, P., DE PADOVA A., M., & Massafra, C. (2004). Testosterone affects pain-related responses differently in male and female rats. NEUROSCIENCE LETTERS, 361, 262-264 [10.1016/j.neulet.2003.12.023].

Testosterone affects pain-related responses differently in male and female rats.

ALOISI, ANNA MARIA;FIORENZANI P;MASSAFRA, COSIMO
2004

Abstract

To evaluate the role of testosterone in pain modulation, we subcutaneously injected male and female rats with testosterone propionate (TP, 5 mg/kg in oil) or oil for 6 days; on the seventh day, all rats were subjected to the formalin test (10%, 50 microl). Behaviours were recorded in an open field (60 min). At the end of the formalin test, the rats were anaesthetized to collect blood from the abdominal aorta. Among the formalin-induced responses, licking was higher in females than males and was decreased by TP in females; jerking and flexing were only slightly affected by treatment. TP increased testosterone plasma levels in both sexes. These results indicate a role of testosterone in modulating formalin-induced responses. The effects appear to be different in males and females.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11365/24417
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