BACKGROUND AND OBJECTIVES: We evaluated clinical and conventional MRI features of a large population of patients with non-disabling MS to identify potential markers of a benign disease course. METHODS: In seven MAGNIMS centres we retrospectively identified 182 patients with benign (B) MS (EDSS score ≤ 3.0, disease duration ≥ 15 years) and 187 patients with non-disabling relapsing-remitting MS (NDRRMS) (Expanded Disability Status Scale score ≤ 3.0, disease duration between 5 and 14 years), in whom clinical data were collected within two weeks from a brain T2-weighted scan. Brain T2 lesion volume (LV) was measured in all patients. In 146 BMS and 146 NDRRMS patients, clinical data were also available after a median follow up of 29 months (range: 7-104 months). RESULTS: Mean LV was higher in BMS than in NDRRMS patients (p<0.001), but the mean ratio between LV and disease duration was higher in NDRRMS than in BMS patients (1.1 vs. 0.6 ml/year, p<0.001). In BMS patients, brain LV was correlated with EDSS score increase at follow up (r=0.18, p=0.03). CONCLUSIONS: An overall low rate of brain LV increase during a long-lasting disease course might be a feature of BMS. In BMS patients, a high brain LV might be associated with worsening of locomotor disability at short-term follow up

Rovaris, M., Rocca, M.a., Barkhof, F., Calabrese, M., DE STEFANO, N., Khalil, M., et al. (2011). Relationship between brain MRI lesion load and short-term disease evolution in non-disabling MS: A large-scale, multicentre study. MULTIPLE SCLEROSIS, 17(3), 319-326 [10.1177/1352458510388824].

Relationship between brain MRI lesion load and short-term disease evolution in non-disabling MS: A large-scale, multicentre study

DE STEFANO, NICOLA;STROMILLO, MARIA LAURA;
2011

Abstract

BACKGROUND AND OBJECTIVES: We evaluated clinical and conventional MRI features of a large population of patients with non-disabling MS to identify potential markers of a benign disease course. METHODS: In seven MAGNIMS centres we retrospectively identified 182 patients with benign (B) MS (EDSS score ≤ 3.0, disease duration ≥ 15 years) and 187 patients with non-disabling relapsing-remitting MS (NDRRMS) (Expanded Disability Status Scale score ≤ 3.0, disease duration between 5 and 14 years), in whom clinical data were collected within two weeks from a brain T2-weighted scan. Brain T2 lesion volume (LV) was measured in all patients. In 146 BMS and 146 NDRRMS patients, clinical data were also available after a median follow up of 29 months (range: 7-104 months). RESULTS: Mean LV was higher in BMS than in NDRRMS patients (p<0.001), but the mean ratio between LV and disease duration was higher in NDRRMS than in BMS patients (1.1 vs. 0.6 ml/year, p<0.001). In BMS patients, brain LV was correlated with EDSS score increase at follow up (r=0.18, p=0.03). CONCLUSIONS: An overall low rate of brain LV increase during a long-lasting disease course might be a feature of BMS. In BMS patients, a high brain LV might be associated with worsening of locomotor disability at short-term follow up
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11365/23759
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