Stroke is one of the most debilitating diseases, and it is unfortunate that only a small percentage of patients can be treated with thrombolytic agents. Consequently, there is an urgent need of finding an alternative procedure for reoxygenating the so-called penumbra at the earliest time as possible for reducing morbidity and disability. A preliminary, preclinical study has been carried out by using rat hippocampal and cortical brain slices subjected to oxygen-glucose deprivation. Oxygen-ozone gaseous mixture appeared to be effective in reverting damage of brain tissues, supporting the evaluation of this approach in well-designed clinical trials in stroke patients.
Frosini, M., Contartese, A., Zanardi, I., Travagli, V., Bocci, V. (2012). Selective ozone concentrations may reduce the ischemic damage after a stroke. FREE RADICAL RESEARCH, 46, 612-618 [10.3109/10715762.2012.659247].
Selective ozone concentrations may reduce the ischemic damage after a stroke
FROSINI, MARIA;CONTARTESE, ANTONELLA;ZANARDI, IACOPO;TRAVAGLI, VALTER;BOCCI, VELIO
2012-01-01
Abstract
Stroke is one of the most debilitating diseases, and it is unfortunate that only a small percentage of patients can be treated with thrombolytic agents. Consequently, there is an urgent need of finding an alternative procedure for reoxygenating the so-called penumbra at the earliest time as possible for reducing morbidity and disability. A preliminary, preclinical study has been carried out by using rat hippocampal and cortical brain slices subjected to oxygen-glucose deprivation. Oxygen-ozone gaseous mixture appeared to be effective in reverting damage of brain tissues, supporting the evaluation of this approach in well-designed clinical trials in stroke patients.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
https://hdl.handle.net/11365/23724
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