Stroke is one of the most debilitating diseases, and it is unfortunate that only a small percentage of patients can be treated with thrombolytic agents. Consequently, there is an urgent need of finding an alternative procedure for reoxygenating the so-called penumbra at the earliest time as possible for reducing morbidity and disability. A preliminary, preclinical study has been carried out by using rat hippocampal and cortical brain slices subjected to oxygen-glucose deprivation. Oxygen-ozone gaseous mixture appeared to be effective in reverting damage of brain tissues, supporting the evaluation of this approach in well-designed clinical trials in stroke patients.
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|Titolo:||Selective ozone concentrations may reduce the ischemic damage after a stroke|
|Citazione:||Frosini, M., Contartese, A., Zanardi, I., Travagli, V., & Bocci, V. (2012). Selective ozone concentrations may reduce the ischemic damage after a stroke. FREE RADICAL RESEARCH, 46, 612-618.|
|Appare nelle tipologie:||1.1 Articolo in rivista|
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