The human TRIP-1 (transforming growth factor-β (TGBβ)-receptor interacting protein-1) cDNA encodes a protein able to associate specifically with the type II TGFβ receptor. It is phosphorylated on serine and threonine by this receptor kinase which makes it a strong candidate as part of the TGFβ signal transduction pathway. We have isolated the genomic sequence of TRIP-1 and found that the complete coding region is organised into 11 exons ranging from 39 to 397 bp and spanning approximately 9 kb of genomic DNA. The 5′ flanking region lacks a TATA box but is GC-rich, suggesting that it is a constitutively expressed gene which is in agreement with its wide pattern of expression. Fluorescence in situ hybridisation mapped the TRIP-1 gene to chromosome 1p34.1 whereas a pseudogene is located on chromosome 7q32.

GALLI STAUBER, G., Raho, G., Rossi, D., Corona, D.F.V., Pirola, B., Bonaglia, M.C., et al. (1998). Genomic Structure and Chromosomal Location of the Human TGFb-receptor Interacting Protein-1 (TRIP-1) Gene to 1p34.1. FEBS LETTERS, 426(2), 279-282 [10.1016/S0014-5793(98)00361-5,].

Genomic Structure and Chromosomal Location of the Human TGFb-receptor Interacting Protein-1 (TRIP-1) Gene to 1p34.1

ROSSI, D.;SORRENTINO, V.
1998

Abstract

The human TRIP-1 (transforming growth factor-β (TGBβ)-receptor interacting protein-1) cDNA encodes a protein able to associate specifically with the type II TGFβ receptor. It is phosphorylated on serine and threonine by this receptor kinase which makes it a strong candidate as part of the TGFβ signal transduction pathway. We have isolated the genomic sequence of TRIP-1 and found that the complete coding region is organised into 11 exons ranging from 39 to 397 bp and spanning approximately 9 kb of genomic DNA. The 5′ flanking region lacks a TATA box but is GC-rich, suggesting that it is a constitutively expressed gene which is in agreement with its wide pattern of expression. Fluorescence in situ hybridisation mapped the TRIP-1 gene to chromosome 1p34.1 whereas a pseudogene is located on chromosome 7q32.
GALLI STAUBER, G., Raho, G., Rossi, D., Corona, D.F.V., Pirola, B., Bonaglia, M.C., et al. (1998). Genomic Structure and Chromosomal Location of the Human TGFb-receptor Interacting Protein-1 (TRIP-1) Gene to 1p34.1. FEBS LETTERS, 426(2), 279-282 [10.1016/S0014-5793(98)00361-5,].
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11365/23598
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