The human TRIP-1 (transforming growth factor-β (TGBβ)-receptor interacting protein-1) cDNA encodes a protein able to associate specifically with the type II TGFβ receptor. It is phosphorylated on serine and threonine by this receptor kinase which makes it a strong candidate as part of the TGFβ signal transduction pathway. We have isolated the genomic sequence of TRIP-1 and found that the complete coding region is organised into 11 exons ranging from 39 to 397 bp and spanning approximately 9 kb of genomic DNA. The 5′ flanking region lacks a TATA box but is GC-rich, suggesting that it is a constitutively expressed gene which is in agreement with its wide pattern of expression. Fluorescence in situ hybridisation mapped the TRIP-1 gene to chromosome 1p34.1 whereas a pseudogene is located on chromosome 7q32.
GALLI STAUBER, G., Raho, G., Rossi, D., Corona, D.F.V., Pirola, B., Bonaglia, M.C., et al. (1998). Genomic Structure and Chromosomal Location of the Human TGFb-receptor Interacting Protein-1 (TRIP-1) Gene to 1p34.1. FEBS LETTERS, 426(2), 279-282 [10.1016/S0014-5793(98)00361-5,].
Genomic Structure and Chromosomal Location of the Human TGFb-receptor Interacting Protein-1 (TRIP-1) Gene to 1p34.1
ROSSI, D.;SORRENTINO, V.
1998-01-01
Abstract
The human TRIP-1 (transforming growth factor-β (TGBβ)-receptor interacting protein-1) cDNA encodes a protein able to associate specifically with the type II TGFβ receptor. It is phosphorylated on serine and threonine by this receptor kinase which makes it a strong candidate as part of the TGFβ signal transduction pathway. We have isolated the genomic sequence of TRIP-1 and found that the complete coding region is organised into 11 exons ranging from 39 to 397 bp and spanning approximately 9 kb of genomic DNA. The 5′ flanking region lacks a TATA box but is GC-rich, suggesting that it is a constitutively expressed gene which is in agreement with its wide pattern of expression. Fluorescence in situ hybridisation mapped the TRIP-1 gene to chromosome 1p34.1 whereas a pseudogene is located on chromosome 7q32.
| File | Dimensione | Formato | |
|---|---|---|---|
|
Galli Stauber et al., 1998.pdf
non disponibili
Tipologia:
Post-print
Licenza:
NON PUBBLICO - Accesso privato/ristretto
Dimensione
104.16 kB
Formato
Adobe PDF
|
104.16 kB | Adobe PDF | Visualizza/Apri Richiedi una copia |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
https://hdl.handle.net/11365/23598
Attenzione
Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo