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Autoantibodies to nAChR are found in 85% of patients with Myasthenia Gravis (seropositive) while in 15% of them the standard immunoprecipitation test for anti-AChR is negative (seronegative). Some of these seronegative patients have antibodies against muscle specific Kinase ( MuSK). The aim of this study is to try to define auto-antibodies against protein different from AChR and MuSK in seronegative patients. We used the cell line TE671, that expresses human AChR. Through our proteomic approach we identified some proteins that could represent potential antigens different from AChR and MuSK.

Trombetta, C.M., Perini, D., Cianti, R., Armini, A., Bini, L., Soldani, P. (2008). Immunoproteomics of myasthenia. In 8th Siena Meeting " From Genome to Proteome : Integration and Proteome Completion (pp.324-324). tipografia senese.

Immunoproteomics of myasthenia

T.r.o.m.b.e.t.t.a.C. M.;ARMINI, ALESSANDRO;BINI, LUCA;SOLDANI, PATRIZIA
2008-01-01

Abstract

Autoantibodies to nAChR are found in 85% of patients with Myasthenia Gravis (seropositive) while in 15% of them the standard immunoprecipitation test for anti-AChR is negative (seronegative). Some of these seronegative patients have antibodies against muscle specific Kinase ( MuSK). The aim of this study is to try to define auto-antibodies against protein different from AChR and MuSK in seronegative patients. We used the cell line TE671, that expresses human AChR. Through our proteomic approach we identified some proteins that could represent potential antigens different from AChR and MuSK.
2008
Trombetta, C.M., Perini, D., Cianti, R., Armini, A., Bini, L., Soldani, P. (2008). Immunoproteomics of myasthenia. In 8th Siena Meeting " From Genome to Proteome : Integration and Proteome Completion (pp.324-324). tipografia senese.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11365/23590
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