Objective: To evaluate the effects after 10 days of an original treatment combining oral progestins with vaginal raloxifene to maximize the antiproliferative effect on the endometrium. Design: Prospective, randomized, clinical pilot study. Setting: Academic research environment. Patient(s): Ninety women with endometrial polyps. Intervention(s): On day 1 of the subsequent menstrual cycle, patients were randomized to receive oral desogestrel (n ¼ 30) for 10 days combined with a tablet of raloxifene (60 mg) per vaginam (group A); oral desogestrel at 60 mg/day (n ¼ 30; group B); or oral danazol at 200 mg, three times a day (n ¼ 30; group C). Main Outcome Measure(s): Ultrasound measurement of endometrial thickness on day 11 of both the pretreatment and treatment cycles, surgeon satisfaction (0 to 10, visual analogue scale), and side effects. Result(s): At the second evaluation, the mean percentage reduction in endometrial thickness in group A was statistically significantly greater than in the other groups. Surgeon satisfaction in terms of endometrial thinning was also greater with group A. Conclusion(s): Oral desogestrel plus vaginal raloxifene provides a fast, low-cost, and satisfactory preparation of the endometrium for operative hysteroscopy. (Fertil Steril 2007;88:698–701. 2007 by American Society for Reproductive Medicine.)
Cicinelli, E., Pinto, V., Tinelli, R., Saliani, N., DE LEO, V., Cianci, A. (2007). Rapid endometrial preparation for hysteroscopic surgery with oral desogestrel plus vaginal raloxifene: a prospective, randomized pilot study. FERTILITY AND STERILITY, 88(3), 698-701 [10.1016/j.fertnstert.2006.11.151].
Rapid endometrial preparation for hysteroscopic surgery with oral desogestrel plus vaginal raloxifene: a prospective, randomized pilot study
DE LEO, V.;
2007-01-01
Abstract
Objective: To evaluate the effects after 10 days of an original treatment combining oral progestins with vaginal raloxifene to maximize the antiproliferative effect on the endometrium. Design: Prospective, randomized, clinical pilot study. Setting: Academic research environment. Patient(s): Ninety women with endometrial polyps. Intervention(s): On day 1 of the subsequent menstrual cycle, patients were randomized to receive oral desogestrel (n ¼ 30) for 10 days combined with a tablet of raloxifene (60 mg) per vaginam (group A); oral desogestrel at 60 mg/day (n ¼ 30; group B); or oral danazol at 200 mg, three times a day (n ¼ 30; group C). Main Outcome Measure(s): Ultrasound measurement of endometrial thickness on day 11 of both the pretreatment and treatment cycles, surgeon satisfaction (0 to 10, visual analogue scale), and side effects. Result(s): At the second evaluation, the mean percentage reduction in endometrial thickness in group A was statistically significantly greater than in the other groups. Surgeon satisfaction in terms of endometrial thinning was also greater with group A. Conclusion(s): Oral desogestrel plus vaginal raloxifene provides a fast, low-cost, and satisfactory preparation of the endometrium for operative hysteroscopy. (Fertil Steril 2007;88:698–701. 2007 by American Society for Reproductive Medicine.)File | Dimensione | Formato | |
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https://hdl.handle.net/11365/23259
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