Estrogens have a variety of effects in addition to their action on reproductive structures, including permanent effects on the Central Nervous System (CNS). Therefore environmental chemicals with estrogenic activity (xenoestrogens) can potentially affect a number of CNS functions. In the present experiment, female rats receiving ethynylestradiol (EE) or methoxychlor (MXC) via the mothers during pregnancy (pre) or lactation (post) were tested in comparison with females born from mothers treated with OIL. The Object Recognition, Plantar and Formalin tests were carried out to evaluate the effects of these compounds on integrated functions such as memory and pain. Testosterone and estradiol plasma levels were determined by RIA. The results of the Object Recognition and Plantar tests did not differ among groups. However the groups differed in the Formalin test since flexing duration was higher in the EE- and MXC-pre groups than in the EE- and MXC-post and OIL groups. Estradiol plasma levels were higher in EE-pre than in the other groups. These results confirm the possibility that estrogen-like compounds (EE and MXC) can affect complex neural processes like pain when taken during critical stages of CNS development

Ceccarelli, I., Fiorenzani, P., DELLA SETA, D., Massafra, C., Cinci, G., Bocci, A., et al. (2009). Perinatal exposure to xenoestrogens affects pain in adult female rats. NEUROTOXICOLOGY AND TERATOLOGY, 31, 203-209 [10.1016/j.ntt.2009.02.004].

Perinatal exposure to xenoestrogens affects pain in adult female rats.

CECCARELLI, ILARIA;FIORENZANI, PAOLO;DELLA SETA, DANIELE;MASSAFRA, COSIMO;CINCI, GIULIANO;ALOISI, ANNA MARIA
2009-01-01

Abstract

Estrogens have a variety of effects in addition to their action on reproductive structures, including permanent effects on the Central Nervous System (CNS). Therefore environmental chemicals with estrogenic activity (xenoestrogens) can potentially affect a number of CNS functions. In the present experiment, female rats receiving ethynylestradiol (EE) or methoxychlor (MXC) via the mothers during pregnancy (pre) or lactation (post) were tested in comparison with females born from mothers treated with OIL. The Object Recognition, Plantar and Formalin tests were carried out to evaluate the effects of these compounds on integrated functions such as memory and pain. Testosterone and estradiol plasma levels were determined by RIA. The results of the Object Recognition and Plantar tests did not differ among groups. However the groups differed in the Formalin test since flexing duration was higher in the EE- and MXC-pre groups than in the EE- and MXC-post and OIL groups. Estradiol plasma levels were higher in EE-pre than in the other groups. These results confirm the possibility that estrogen-like compounds (EE and MXC) can affect complex neural processes like pain when taken during critical stages of CNS development
Ceccarelli, I., Fiorenzani, P., DELLA SETA, D., Massafra, C., Cinci, G., Bocci, A., et al. (2009). Perinatal exposure to xenoestrogens affects pain in adult female rats. NEUROTOXICOLOGY AND TERATOLOGY, 31, 203-209 [10.1016/j.ntt.2009.02.004].
File in questo prodotto:
File Dimensione Formato  
Lav 2009- Neurotox-Ter.pdf

non disponibili

Tipologia: Post-print
Licenza: NON PUBBLICO - Accesso privato/ristretto
Dimensione 424.68 kB
Formato Adobe PDF
424.68 kB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11365/22966
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo