Several derivatives of thiosemicarbazones and their iron and copper complexes have been studied for their cytotoxicity and inhibiting activity against DNA synthesis. In the present work complexes formed in H2O–DMSO solution between copper(II) and the acetophenone thiosemicarbazone (ATSC) and the o-aminobenzaldehyde thiosemicarbazone (o-NH2TSC) have been studied. EPR studies have been performed at different pH values and metal-to-ligand ratios. The spectra have been recorded at both room (298 K) and low temperatures (120 K). A possible relationship between structure and activity is attempted on the basis of the EPR data.
Pogni, R., Baratto, M.C., Diaz, A., Basosi, R. (2000). EPR Characterization of Mono(Thiosemicarbazones) Copper(II) Complexes. Note II. JOURNAL OF INORGANIC BIOCHEMISTRY, 79, 333-337 [10.1016/S0162-0134(99)00166-X].
EPR Characterization of Mono(Thiosemicarbazones) Copper(II) Complexes. Note II
POGNI, REBECCA;BARATTO, MARIA CAMILLA;BASOSI, RICCARDO
2000-01-01
Abstract
Several derivatives of thiosemicarbazones and their iron and copper complexes have been studied for their cytotoxicity and inhibiting activity against DNA synthesis. In the present work complexes formed in H2O–DMSO solution between copper(II) and the acetophenone thiosemicarbazone (ATSC) and the o-aminobenzaldehyde thiosemicarbazone (o-NH2TSC) have been studied. EPR studies have been performed at different pH values and metal-to-ligand ratios. The spectra have been recorded at both room (298 K) and low temperatures (120 K). A possible relationship between structure and activity is attempted on the basis of the EPR data.
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https://hdl.handle.net/11365/22851
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