In a drug-resistant epilepsy patient with continuous forearm/hand positive myoclonia due to a focal cortical dysplasia of the right motor cortex, cortical jerk-related and electromyographic activity were recorded for 15 min before and after 1 Hz rTMS (15 min, 10% below the resting excitability threshold) of the right motor cortex. A stable negative cortical spike, time-locked with contralateral muscle jerks (60 > 100 microV), was detected only at perirolandic electrodes (maximal amplitudes: block 1 = 21.3 microV, block 2 = 22 microV, block 3 = 25.9 microV). After rTMS, only 20 muscle jerks accomplished the criterion of > 100 microV; blind back-averaging of these disclosed a topographically similar cortical spike, but with amplitude reduced by at least 50% (11.2 microV). This represents in vivo evidence of the possibility to selectively modulate the activity of an epileptic focus by intervening with local low-frequency rTMS.

Rossi, S., Ulivelli, M., Bartalini, S., Galli, R., Passero, S.G., Battistini, N., et al. (2004). Reduction of cortical myoclonus-related epileptic activity following slow-frequency rTMS. NEUROREPORT, 15(2), 293-296 [10.1097/00001756-200402090-00016].

Reduction of cortical myoclonus-related epileptic activity following slow-frequency rTMS.

ROSSI, SIMONE;ULIVELLI, MONICA;PASSERO, STEFANO GIACOMO;BATTISTINI, NOE';
2004-01-01

Abstract

In a drug-resistant epilepsy patient with continuous forearm/hand positive myoclonia due to a focal cortical dysplasia of the right motor cortex, cortical jerk-related and electromyographic activity were recorded for 15 min before and after 1 Hz rTMS (15 min, 10% below the resting excitability threshold) of the right motor cortex. A stable negative cortical spike, time-locked with contralateral muscle jerks (60 > 100 microV), was detected only at perirolandic electrodes (maximal amplitudes: block 1 = 21.3 microV, block 2 = 22 microV, block 3 = 25.9 microV). After rTMS, only 20 muscle jerks accomplished the criterion of > 100 microV; blind back-averaging of these disclosed a topographically similar cortical spike, but with amplitude reduced by at least 50% (11.2 microV). This represents in vivo evidence of the possibility to selectively modulate the activity of an epileptic focus by intervening with local low-frequency rTMS.
Rossi, S., Ulivelli, M., Bartalini, S., Galli, R., Passero, S.G., Battistini, N., et al. (2004). Reduction of cortical myoclonus-related epileptic activity following slow-frequency rTMS. NEUROREPORT, 15(2), 293-296 [10.1097/00001756-200402090-00016].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11365/22771
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