11 beta-Hydroxysteroid dehydrogenase type 1 (11 beta HSD1) is a NADP(H)-dependent oxidoreductase of the ER lumen, which may have an important role in the pathogenesis of metabolic syndrome. Here, the functional coupling of 11 beta-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase (H6PDH) was investigated in rat liver microsomal vesicles. The results demonstrate the existence of a separate intraluminal pyridine nucleotide pool in the hepatic endoplasmic reticulum and a close cooperation between 11 beta PHSD1 and H6PDH based on their co-localization and the mutual generation of cofactors for each other. (c) 2005 Elsevier Ireland Ltd. All rights reserved.

Czegle, I., Piccirella, S., Senesi, S., Csala, M., Mandl, J., Banhegyi, G., et al. (2006). Cooperativity between 11beta-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase is based on a common pyridine nucleotide pool in the lumen of the endoplasmic reticulum. MOLECULAR AND CELLULAR ENDOCRINOLOGY, 248(1-2), 24-25 [10.1016/j.mce.2005.10.018].

Cooperativity between 11beta-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase is based on a common pyridine nucleotide pool in the lumen of the endoplasmic reticulum

PICCIRELLA, S.;SENESI, S.;FULCERI, R.;BENEDETTI, A.
2006-01-01

Abstract

11 beta-Hydroxysteroid dehydrogenase type 1 (11 beta HSD1) is a NADP(H)-dependent oxidoreductase of the ER lumen, which may have an important role in the pathogenesis of metabolic syndrome. Here, the functional coupling of 11 beta-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase (H6PDH) was investigated in rat liver microsomal vesicles. The results demonstrate the existence of a separate intraluminal pyridine nucleotide pool in the hepatic endoplasmic reticulum and a close cooperation between 11 beta PHSD1 and H6PDH based on their co-localization and the mutual generation of cofactors for each other. (c) 2005 Elsevier Ireland Ltd. All rights reserved.
Czegle, I., Piccirella, S., Senesi, S., Csala, M., Mandl, J., Banhegyi, G., et al. (2006). Cooperativity between 11beta-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase is based on a common pyridine nucleotide pool in the lumen of the endoplasmic reticulum. MOLECULAR AND CELLULAR ENDOCRINOLOGY, 248(1-2), 24-25 [10.1016/j.mce.2005.10.018].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11365/21770
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