This paper describes a method for voriconazole assay in pharmaceuticals by using differential pulse polarography (DPP). The voriconazole standard was obtained from pharmaceutical formulations and its purity determined by LC/UV, LC/ESI/MS and DSC analyses. In the DPP analysis a well defined peak (-1.01 V, vs. Ag/AgCl), useful for an accurate and precise assay, was obtained using a 0.01 M KH2PO4 water solution (pH 4.5) as supporting electrolyte. The analytical procedure was successfully applied to the voriconazole determination in tablets and injectables.
Corbini, G., Zanfini, A., LA ROSA, C., D'Arpino, A., Meucci, R., Dreassi, E. (2009). Polarographic Determination of Voriconazole in Pharmaceutical Formulations. CURRENT ANALYTICAL CHEMISTRY, 5(3), 238-243 [10.2174/157341109788680282].
Polarographic Determination of Voriconazole in Pharmaceutical Formulations
CORBINI, GIANFRANCO;ZANFINI, ASSUNTA;LA ROSA, CATERINA;DREASSI, ELENA
2009-01-01
Abstract
This paper describes a method for voriconazole assay in pharmaceuticals by using differential pulse polarography (DPP). The voriconazole standard was obtained from pharmaceutical formulations and its purity determined by LC/UV, LC/ESI/MS and DSC analyses. In the DPP analysis a well defined peak (-1.01 V, vs. Ag/AgCl), useful for an accurate and precise assay, was obtained using a 0.01 M KH2PO4 water solution (pH 4.5) as supporting electrolyte. The analytical procedure was successfully applied to the voriconazole determination in tablets and injectables.
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https://hdl.handle.net/11365/21709
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