In this paper the combined use of in vivo (13)C-nuclear magnetic resonance spectroscopy and mathematical modelling allowed the analysis of the response to ethanol stress in a wild-type strain of Saccharomyces cerevisiae, in terms of a reduced metabolic activity. The model developed succeeded in describing and interpreting the effects of increasing concentrations of exogenous ethanol. In particular, the ratio between the kinetic constants associated with ethanol production and glucose consumption gave the estimation of the metabolic yield of the processes in perfect agreement with experimental results.

Martini, S., Ricci, M., Bonechi, C., Trabalzini, L., Santucci, A., Rossi, C. (2004). In vivo C-13-NMR and modelling study of metabolic yield response to ethanol stress in a wild-type strain of Saccharomyces cerevisiae. FEBS LETTERS, 564(1-2), 63-68 [10.1016/S0014-5793(04)00316-3].

In vivo C-13-NMR and modelling study of metabolic yield response to ethanol stress in a wild-type strain of Saccharomyces cerevisiae

MARTINI, SILVIA;RICCI, MASO;BONECHI, CLAUDIA;TRABALZINI, LORENZA;SANTUCCI, ANNALISA;ROSSI, CLAUDIO
2004-01-01

Abstract

In this paper the combined use of in vivo (13)C-nuclear magnetic resonance spectroscopy and mathematical modelling allowed the analysis of the response to ethanol stress in a wild-type strain of Saccharomyces cerevisiae, in terms of a reduced metabolic activity. The model developed succeeded in describing and interpreting the effects of increasing concentrations of exogenous ethanol. In particular, the ratio between the kinetic constants associated with ethanol production and glucose consumption gave the estimation of the metabolic yield of the processes in perfect agreement with experimental results.
2004
Martini, S., Ricci, M., Bonechi, C., Trabalzini, L., Santucci, A., Rossi, C. (2004). In vivo C-13-NMR and modelling study of metabolic yield response to ethanol stress in a wild-type strain of Saccharomyces cerevisiae. FEBS LETTERS, 564(1-2), 63-68 [10.1016/S0014-5793(04)00316-3].
File in questo prodotto:
File Dimensione Formato  
2004_FEBSlett.pdf

non disponibili

Tipologia: Post-print
Licenza: NON PUBBLICO - Accesso privato/ristretto
Dimensione 437.42 kB
Formato Adobe PDF
437.42 kB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11365/21644
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo